COSS 2024 NEU 380 Refs

Reference List - COSS 2024 Posters #72 - #74
"Beyond LEO: Human Factors of Long-Duration Space Travel"
NEU 380 - Human Neurophysiology of Space Travel, Stress, and Hormones
Mars Mission References:

Gupta, U., Baig, S., Majid, A., & Bell, S. M. (2023). The neurology of space flight; How does space flight effect the human nervous system?. Life sciences in space research, 36, 105–115. https://doi.org/10.1016/j.lssr.2022.09.003 

Dinatolo, M. F., & Cohen, L. Y. (2022). Monitoring the Impact of Spaceflight on the Human Brain. Life (Basel, Switzerland), 12(7), 1060. https://doi.org/10.3390/life12071060 

Takamatsu, Y., Koike, W., Takenouchi, T., Sugama, S., Wei, J., Waragai, M., Sekiyama, K., & Hashimoto, M. (2016). Protection against neurodegenerative disease on Earth and in space. NPJ microgravity, 2, 16013. https://doi.org/10.1038/npjmgrav.2016.13 

Boyle, R., & Varelas, J. (2021). Otoconia Structure After Short- and Long-Duration Exposure to Altered Gravity. Journal of the Association for Research in Otolaryngology : JARO, 22(5), 509–525. https://doi.org/10.1007/s10162-021-00791-6 

Carriot, J., Mackrous, I., & Cullen, K. E. (2021). Challenges to the Vestibular System in Space: How the Brain Responds and Adapts to Microgravity. Frontiers in neural circuits, 15, 760313. https://doi.org/10.3389/fncir.2021.760313 

Clément, G. R., Boyle, R. D., George, K. A., Nelson, G. A., Reschke, M. F., Williams, T. J., & Paloski, W. H. (2020). Challenges to the central nervous system during human spaceflight missions to Mars. Journal of Neurophysiology. https://doi.org/JN-00476-2019 

Hupfeld, K. E., McGregor, H. R., Koppelmans, V., Beltran, N. E., Kofman, I. S., De Dios, Y. E., Riascos, R. F., Reuter-Lorenz, P. A., Wood, S. J., Bloomberg, J. J., Mulavara, A. P., Seidler, R. D. (2022). Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight. Cerebral cortex (New York, N.Y. : 1991), 32(4), 755–769. https://doi.org/10.1093/cercor/bhab239 

Mackrous, I., Carriot, J., Jamali, M., & Cullen, K. E. (2019). Cerebellar Prediction of the Dynamic Sensory Consequences of Gravity. Current biology : CB, 29(16), 2698– 2710.e4. https://doi.org/10.1016/j.cub.2019.07.006 

Vestibular System [Photograph]. Griffin Occupation Therapy. https://www.griffinot.com/vestibular-system/  

Bonanni, R., Cariati, I., Marini, M., Tarantino, U., & Tancredi, V. (2023). Microgravity and Musculoskeletal Health: What Strategies Should Be Used for a Great Challenge? Life, 13(7), 1423. https://doi.org/10.3390/life13071423 

Furukawa, S., Chatani, M., Higashitani, A., Higashibata, A., Kawano, F., Nikawa, T., Numaga-Tomita, T., Ogura, T., Sato, F., Sehara-Fujisawa, A., Shinohara, M., Shimazu, T., Takahashi, S., & Watanabe-Takano, H. (2021). Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth. Npj Microgravity, 7(1), 1–10. https://doi.org/10.1038/s41526-021-00145-9 

Issertine, M., Rosa-Calwell, M. E., Sung, D.-M., Bouxsein, M. L., Rutkove, S. B., & Mortreux, M. (2024). Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery. Physiological Reports, 12(4), e15938. https://doi.org/10.14814/phy2.15938 

Schoenrock, B., Muckelt, P. E., Hastermann, M., Albracht, K., MacGregor, R., Martin, D., Hans-Christian Gunga, Salanova, M., Stokes, M. J., Warner, M. B., & Dieter Blottner. (2024). Muscle stiffness indicating mission crew health in space. Scientific Reports, 14(1). https://doi.org/10.1038/s41598-024-54759-6 

Crucian, B. E., Makedonas, G., Sams, C. F., Pierson, D. L., Simpson, R., Stowe, R. P., Smith, S. M., Zwart, S. R., Krieger, S. S., Rooney, B., Douglas, G., Downs, M., Nelman-Gonzalez, M., Williams, T. J., & Mehta, S. (2020). Countermeasures-based improvements in stress, immune system dysregulation and latent herpesvirus reactivation onboard the International Space Station – relevance for deep space missions and Terrestrial Medicine. Neuroscience & Biobehavioral Reviews, 115, 68–76. https://doi.org/10.1016/j.neubiorev.2020.05.007 

Mehta, S. K., Laudenslager, M. L., Stowe, R. P., Crucian, B. E., Feiveson, A. H., Sams, C. F., & Pierson, D. L. (2017). Latent virus reactivation in astronauts on the international space station. NPJ microgravity, 3, 11. https://doi.org/10.1038/s41526-017-0015-y 

Siddiqui, R., Qaisar, R., Goswami, N., Khan, N. A., & Elmoselhi, A. (2021). Effect of Microgravity Environment on Gut Microbiome and Angiogenesis. Life (Basel, Switzerland), 11(10), 1008. https://doi.org/10.3390/life11101008 

Sonnenfeld G. (2002). The immune system in space and microgravity. Medicine and science in sports and exercise, 34(12), 2021–2027. https://doi.org/10.1097/00005768-200212000-00024 

Tesei, D., Jewczynko, A., Lynch, A. M., & Urbaniak, C. (2022). Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions. Life (Basel, Switzerland), 12(4), 495. https://doi.org/10.3390/life12040495 

Alfano, C. A., Bower, J. L., Cowie, J., Lau, S., & Simpson, R. J. (2018). Long-duration Space Exploration and Emotional Health: Recommendations for conceptualizing and evaluating risk. Acta Astronautica, 142, 289–299. https://doi.org/10.1016/j.actaastro.2017.11.009 

Arone, A., Ivaldi, T., Loganovsky, K., Palermo, S., Parra, E., Flamini, W., & Marazziti, D. (2021). The Burden of Space Exploration on the Mental Health of Astronauts: A Narrative Review. Clinical neuropsychiatry,18(5), 237–246. https://doi.org/10.36131/cnfioritieditore20210502 

Doarn, C., Polk, J., & Shepanek, M. (2019). Health challenges including behavioral problems in 

long-duration spaceflight. Neurology India, 67(8), 190. https://doi.org/10.4103/0028-3886.259116 

Oluwafemi, F. A., Abdelbaki, R., Lai, J. C.-Y., Mora-Almanza, J. G., & Afolayan, E. M. (2021). A review of Astronaut Mental Health in manned missions: Potential Interventions for Cognitive and mental health challenges. Life Sciences in Space Research, 28, 26–31. https://doi.org/10.1016/j.lssr.2020.12.002 

Salamon, N. (2017). Application of Virtual Reality for Crew Mental Health in Extended-Duration Space Missions. https://doi.org/10.26226/morressier.59c106e7d462b80292389aca 

Arzeno, N. M., Stenger, M. B., Bloomberg, J. J., & Platts, S. H. (2013). Spaceflight-induced cardiovascular changes and recovery during NASA’s Functional Task Test. Acta Astronautica, 92(1), 10–14. https://doi.org/10.1016/j.actaastro.2012.05.023 

Jordan, J., Limper, U., & Tank, J. (2022). Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine. Neurological Sciences, 43(5), 3039–3051. https://doi.org/10.1007/s10072-022-05963-7 

Mark, S., Scott, G., Donoviel, D. B., Leveton, L. B., Mahoney, E., Charles, J. B., & Siegel, B. (2014). The Impact of Sex and Gender on Adaptation to Space: Executive Summary. Journal of Womens Health, 23(11), 941 947. https://doi.org/10.1089/jwh.2014.4914  

Giacinto, O., Lusini, M., Sammartini, E., Minati, A., Mastroianni, C., Nenna, A., Porcellini, G., Sammartini, D., Carassiti, M., Miraldi, F., Chello, M., & Pelliccia, F. (2024). Cardiovascular effects of cosmic radiation and microgravity. Journal of Clinical Medicine, 13(2), 520. https://doi.org/10.3390/jcm13020520 

Moon Mission References:

Bloomberg, J., Carpenter, R.D., Cavanagh P.R, Frassetto, L., Funk, J., Grodsinsky, C., Hanson, A.M., Kornak, J., Lang, T., Lee, S.M.C., Mulavara, A., Saeed, I., Sibonga, J., Spiering, B.A., Streeper, T. (2010). Development of an Integrated Countermeasure Device for Use in Long-Duration Spaceflight. Acta Astronautica. 2011, 16, 2029-2037; doi: 10.1016/j.actaastro.2010.11.002  

Blottner, D., Salanova, M., Püttmann, B., Schiffl, G., Felsenberg, D., Buehring, B., Rittweger, J. (2006). Human Skeletal Muscle Structure and Function Preserved by Vibration Muscle Exercise Following 55 days of Bed Rest. Eur J Appl Physiol (2006) 97: 261–271; doi: 10.1007/s00421-006-0160-6 

Caplan, N., Fiebig, L., Green, A., Kim, D., Sandal, P.H., Weber, T., Winnard, A. (2020). Effectiveness of Nutritional Countermeasures in Microgravity and its Ground-Based Analogues to Ameliorate Musculoskeletal and Cardiopulmonary Deconditioning–A Systematic Review. PLoS One (2020) 15(6): 1-16; doi 10.1007/s00421-006-0160-6 

Cleather, D. Kennet, J. (2021, Nov 5). Teddington pilates teacher invents exercise machine for astronauts. Teddington Nub News. https://teddington.nub.news/news/local-news/teddington-pilates-teacher-invents-exercise-machine-for-astronauts 

Globus, R.K., & Tahimic C.G.T. (2017). Redox Signaling and its Impact on Skeletal and Vascular Responses to Spaceflight. Int. J. Mol. Sci. 2017, 18, 2153; doi:10.3390/ijms18102153 

Jia, B., Xie, L., Zheng, Q., Yang, P., Zhang, W., Ding, C., Qian, A., Shang, P. (2014). A Hypomagnetic Field Aggravates Bone Loss Induced by Hindlimb Unloading in Rat Femurs. PLoS One. 9(8): e105604. doi: 10.1371/journal.pone.0105604 

Gan, X., Zhao, J., Li, S., Kan, G., Zhang, Y., Wang, B., … Guo, J. (2024). Simulated space    environmental factors of weightlessness, noise and low atmospheric pressure differentially affect the diurnal rhythm and the gut microbiome. Life Sciences in Space Research, 40, 115-125. https://doi.org/10.1016/j.lssr.2023.09.006 

Jiang, P., Green, S. J., Chlipala, G. E., Turek, F. W., & Vitaterna, M. H. (2019). Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight. Microbiome, 7(1), 113. https://doi.org/10.1186/s40168-019-0724-4 

Mortazavi, S. M. J., Said-Salman, I., Mortazavi, A. R., El Khatib, S., & Sihver, L. (2023, December 5). How the adaptation of the human microbiome to harsh space environment can determine the chances of success for a space mission to Mars and beyond. Frontiers. https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1237564/full 

Siddiqui, R., Akbar, N., & Khan, N. A. (2020). Gut microbiome and human health under the space environment. Journal of Applied Microbiology, 130(1), 14–24. https://doi.org/10.1111/jam.14789 

Siddiqui, R., Qaisar, R., Al-Dahash, K., Altelly, A. H., Elmoselhi, A. B., & Khan, N. A. (2024). Cardiovascular changes under the microgravity environment and the gut microbiome. Life Sciences in Space Research, 40, 89-96. https://doi.org/10.1016/j.lssr.2023.09.003 

Siddiqui, R. et al. (2021) Effect of microgravity environment on gut microbiome and angiogenesis, MDPI. Available at: https://www.mdpi.com/2075-1729/11/10/1008 (Accessed: 29 February 2024). 

Baran, R., Marchal, S., Campos, S. G., Rehnberg, E., Tabury, K., Baselet, B., Wehland, M., Grimm, D., & Baatout, S. (2022). The Cardiovascular System in Space: Focus on In Vivo and In Vitro Studies. Biomedicines. 10(59). https://doi.org/10.3390/biomedicines10010059. 

Beheshti, A., McDonald, J. T., Miller, J., Grabham, P., & Costes, S. V. (2019). GeneLab Database Analyses Suggest Long-Term Impact of Space Radiation on the Cardiovascular System by the Activation of FYN Through Reactive Oxygen Species. International Journal of Molecular Sciences. 20(661). Doi: 10.3390/ijms20030661.   

Camberos, V., Baio, J., Mandujano, A., Martinez, A. F., Bailey, L., Hasaniya, N., & Kearns- Jonker, M. (2021). The Impact of Spaceflight and Microgravity on the Human Islet-1+ Cardiovascular Progenitor Cell Transcriptome. International Journal of Molecular Sciences. 22(3577).  https://doi.org/10.3390/ijms22073577. 

Garret-Bakelman et al. (2019). The NASA Twins Study: A multidimensional analysis of a year- long human spaceflight. Science364(6436). Doi:10.1126/science.aau8650.  

Mencia-Trinchant, N., MacKay, M. J., Chin, C., Levine, R. L., Hassane, D. C., & Mason, C. E. (2020). Clonal Hematopoiesis Before, During, and After Human Spaceflight. Cell Reports. 33(108458). https://doi.org/10.1016/j.celrep.2020.108458  

Norsk, P. (2019). Adaptation of the cardiovascular system to weightlessness: Suprises, paradoxes and Implications for deep space missions. Acta Physiologica. Doi: 10.1111/apha.13434. 

Pagnini, F., Manzey, D., Rosnet, E., Ferravante, D., White, O., & Smith, N. (2023). Human behavior and performance in deep space exploration: next challenges and research gaps. NPJ microgravity, 9(1), 27. https://doi.org/10.1038/s41526-023-00270-7 

Yin, Y., Liu, J., Fan, Q. et al. Long-term spaceflight composite stress induces depression and cognitive impairment in astronauts—insights from neuroplasticity. Transl Psychiatry13, 342 (2023). https://doi.org/10.1038/s41398-023-02638-5 

Funmilola A. Oluwafemi, Rayan Abdelbaki, James C.-Y. Lai, Jose G. Mora-Almanza, Esther M. Afolayan,A review of astronaut mental health in manned missions: Potential interventions for cognitive and mental health challenges,Life Sciences in Space Research,Volume 28,2021,Pages 26-31,ISSN 2214-5524,https://doi.org/10.1016/j.lssr.2020.12.002. 

Pandi-Perumal, S. R., & Gonfalone, A. A. (2016). Sleep in space as a new medical frontier: the challenge of preserving normal sleep in the abnormal environment of space missions. Sleep science (Sao Paulo, Brazil), 9(1), 1–4. https://doi.org/10.1016/j.slsci.2016.01.003 

Arone, A., Ivaldi, T., Loganovsky, K., Palermo, S., Parra, E., Flamini, W., & Marazziti, D. (2021). The Burden of Space Exploration on the Mental Health of Astronauts: A Narrative Review. Clinical neuropsychiatry, 18(5), 237–246. https://doi.org/10.36131/cnfioritieditore20210502 

Hallgren, E., Migeotte, P.-F., Kornilova, L., Delière, Q., Fransen, E., Glukhikh, D., Moore, S. T., Clément, G., Diedrich, A., MacDougall, H., & Wuyts, F. L. (2015). Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space. Scientific Reports, 5(1), 17627. https://doi.org/10.1038/srep17627 

Waisberg, E., Ong, J., Masalkhi, M., Mao, X. W., Beheshti, A., & Lee, A. G. (2024). Mitochondrial dysfunction in Spaceflight Associated Neuro-Ocular Syndrome (SANS): A molecular hypothesis in pathogenesis. Eye. https://doi.org/10.1038/s41433-024-02951-3 

Shishkin, N., Kitov, V., Sayenko, D., & Tomilovskaya, E. (2023). Sensory organization of postural control after long term space flight. Frontiers in Neural Circuits, 17, 1135434. https://doi.org/10.3389/fncir.2023.1135434 

Reschke, M. F., Good, E. F., & Clément, G. R. (2017). Neurovestibular Symptoms in Astronauts Immediately after Space Shuttle and International Space Station Missions. OTO Open, 1(4), 2473974X17738767. https://doi.org/10.1177/2473974X17738767 

Koch, A., Cascorbi, I., Westhofen, M., Dafotakis, M., Klapa, S., & Kuhtz-Buschbeck, J. P. (2018). The Neurophysiology and Treatment of Motion Sickness. Deutsches Arzteblatt international, 115(41), 687–696. https://doi.org/10.3238/arztebl.2018.0687 

Isasi, E., Isasi, M. E., & Van Loon, J. J. W. A. (2022). The application of artificial gravity in medicine and space. Frontiers in Physiology, 13, 952723. https://doi.org/10.3389/fphys.2022.952723